We have had a pleasant stay at hotel Alessandrino. It was nicely priced for a hotel in Rome. The room was clean, which is for us one of the most important things. The hotel staff was nice, relaxted and helpfull. Our room was small but it was ok for city trip. Bathroom could use a upgrade, rainshower was not ok anymore, but normal showerhead worked fine.
Downside of our room was mainly the noice from washing machines, cleaning and reception at all possible hours. The wall do not isolate any sound.
Location wise it is not typically in the most exiting area. It is great for going to the vatican, but little bit more far to other large attractions. It is walkable to center but expect times of 45minutes. Otherwise take a bus (8min walk) or other means of transport.
I think for what you pay you get a fair room.