Photo by Janine Chrispin

Hotels in Santo Antonio

your current months are December, 2024 and January, 2025.
December 2024
January 2025

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Where to stay in Santo Antonio?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Santo Antonio

Frequently asked questions

Can I book a refundable hotel in Santo Antonio?
If you need the flexibility to change your plans to Santo Antonio, most accommodations offer refundable* bookable rates. You can see these properties by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay in Santo Antonio if I want a vacation home instead of a hotel?
If you want a good alternative to a hotel, review our selection of 21 vacation homes. You can also book one of 35 apartments or 15 villas.
What will the weather in Santo Antonio be like during my vacation?
August and July are typically the warmest months in Santo Antonio when the average temp is 67°F. February and March are the coldest months when the average temperature is 56°F. December and November are the months with the most rain.
Why should I book my Santo Antonio hotel through Hotels.com?
There are lots of reasons to book your Santo Antonio trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.